café scientifique

Next Meeting:

Monday 11th February 2019
“Heart Rate in Heart Failure – a new approach for an old measure”
By Klaus Witte

Heart rate is the most basic measure of heart function and is almost the first thing that every doctor checks. A ‘too slow’ or ‘too fast’ heart beat is a common cause of symptoms and can be treated with tablets or a pacemaker. But what is ‘too slow’ or ‘too fast’? Surely everyone is an individual – how can we assess what’s ‘too slow’ or ‘too fast’ and do the normal rules apply to people with heart problems.

Dr Witte is an expert in heart failure, pacemaker therapy and has spent the last fifteen years exploring heart rate and its effects on exercise capacity and will describe a new technique for assessing the optimal heart rate range in any individual and the benefits in some of controlling the heart rate to within that range.


Klaus Witte is a Senior Lecturer and Consultant Cardiologist in the Leeds Institute of Cardiovascular and Metabolic Medicine at the University of Leeds. His research interests include vitamin D in CHF, and he was the principle investigator of the largest study of vitamin D supplementation in CHF which showed a clinically important increase in LV function following one year of vitamin D.

His work on the influence of heart rate on exercise capacity in heart failure, around the hypothesis that exercise intolerance in heart failure is not the result of poor heart rate rise (chronotropic incompetence) took a step forward following a series of studies collated in 2016. He has subsequently described, using a reproducible non-invasive technique to measure the force-frequency relationship developed in Leeds, that patients with heart failure have a flat force frequency slope, and low peak contractility which occurs at a lower heart rate than in controls. This finding and a short term randomised cross-over study describing the benefit on exercise capacity of programming pacemakers using patients’ own force frequency relationship information were published in JACC-HF in September 2017.



About Café Scientifique

Café Scientifique is a place where people can meet to hear eminent speakers on all things scientific. The events are extremely popular with lively discussion and informative talks. Topics are always relevant, cutting edge and up-to-date. They are often taken from a wider global discussion.

All are welcome. The Café is held at The New Headingley Club on St Michael’s Road.

For information on topics please check back here for updates or for more information see the e-newsletter or the HDT newsletter.

To be added to the Café Scientifique mailing list please fill out the online form opposite.


Click here for details of previous talks

Coming soon:

Monday 11th February
Heart Rate in Heart Failure – a new approach
By Klaus Witte

Monday 11th March
Turbulent Clouds: Troublemakers in Weather and Climate Models
By Steven Boeing

Monday 8th April
Flood Risks in Leeds and the Flood Alleviation Scheme
By David Wilkes


what's on

  • Projects and Events

    HDT Projects and EventsVisit page

  • Talking Heads

    Thurs 10th January - "Unlocking Sustainable Cities" by Paul ChattertonVisit page

  • Café Scientifique

    Mon 11th February - Heart Rate in Heart Failure: a new approachVisit page

  • Films at HEART

    Tuesday 12th February 8pm - "Mr Kaplan"Visit page

  • Farmers Market

    Sat 9th February 2019Visit page

  • Zero Carbon Headingley

    Wednesday February 13th - Next Meeting in HeartVisit page

@HDTHeadingley on Twitter

additional info

7:30pm – 9:30pm

New Headingley Club
56 St Michael’s Road
Tel: 0113 2757712 (for info. on venue)

Entry £3

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